The Global Innovation Index 2016 attempts to understand the globalization of innovation in its various permutations and combinations to analyse the ways in which this is a positive-sum game where all stakeholders stand to gain. In addition, the present edition of the GII seeks to present the case for an extension of policy approaches that goes beyond national priorities towards global innovation cooperation, especially South–South cooperation. The GII 2016 includes chapters containing powerful insights from some of the most influential policy makers, academics, and industrialists in the world. These chapters expand the knowledge base on global innovation, and they demonstrate how national policies for innovation should be aligned with tackling global needs and geared towards solving global challenges.